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Overview
About this package
This package provides functions to fetch, explore, and reproduce the processed data and downstream analysis results presented in the main paper for the first large-scale multi-omic multi-tissue endurance exercise training study conducted in young adult rats by the Molecular Transducers of Physical Activity Consortium (MoTrPAC). See our publication in Nature. See the vignette for examples of how to use this package.
While some of the functions in this package can be used by themselves, they were primarily written to analyze data in the MotrpacRatTraining6moData R package. See examples of how these data can be analyzed without this package in the MotrpacRatTraining6moData vignette.
About MoTrPAC
MoTrPAC is a national research consortium designed to discover and perform preliminary characterization of the range of molecular transducers (the “molecular map”) that underlie the effects of physical activity in humans. The program’s goal is to study the molecular changes that occur during and after exercise and ultimately to advance the understanding of how physical activity improves and preserves health. The six-year program is the largest targeted NIH investment of funds into the mechanisms of how physical activity improves health and prevents disease. See motrpac.org and motrpac-data.org for more details.
Installation
Install this package with devtools. Because installing this package also installs MotrpacRatTraining6moData as a dependency, Mac users should additionally extend their timeout to prevent an error caused by the amount of time it takes to download MoTrPAC/MotrpacRatTraining6moData@HEAD.
options(timeout=1e5) # recommended for Mac users
if (!require("devtools", quietly = TRUE)){
install.packages("devtools")
}
devtools::install_github("MoTrPAC/MotrpacRatTraining6mo")MotrpacRatTraining6moData is a critical dependency for this package. If the above command has issues installing this dependency, follow these instructions to install MotrpacRatTraining6moData separately.
Getting help
See the vignette for examples of how to use this package. Still have questions? For questions, bug reporting, and feature requests for this package, please submit a new issue and include as many details as possible.
If the concern is related to data provided in the MotrpacRatTraining6moData package, please submit an issue here instead.
Acknowledgements
MoTrPAC is supported by the National Institutes of Health (NIH) Common Fund through cooperative agreements managed by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Arthritis and Musculoskeletal Diseases (NIAMS), and National Institute on Aging (NIA). Specifically, the MoTrPAC Study is supported by NIH grants U24OD026629 (Bioinformatics Center), U24DK112349, U24DK112342, U24DK112340, U24DK112341, U24DK112326, U24DK112331, U24DK112348 (Chemical Analysis Sites), U01AR071133, U01AR071130, U01AR071124, U01AR071128, U01AR071150, U01AR071160, U01AR071158 (Clinical Centers), U24AR071113 (Consortium Coordinating Center), U01AG055133, U01AG055137 and U01AG055135 (PASS/Animal Sites).
Data use agreement
Recipients and their Agents agree that in publications using any data from MoTrPAC public-use data sets they will acknowledge MoTrPAC as the source of data, including the version number of the data sets used, e.g.:
Data used in the preparation of this article were obtained from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) database, which is available for public access at motrpac-data.org. Specific datasets used are [version numbers].
Data used in the preparation of this article were obtained from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) MotrpacRatTraining6moData R package [version number].
Citing MoTrPAC data
MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature 629, 174–183 (2024). https://doi.org/10.1038/s41586-023-06877-w