Comparisons of adipocyte diameter between timepoints using a negative binomial regression model.
ADIPOCYTE_SIZE_STATSA data.frame with 40 rows and 11 variables:
factor; the comparison being made ("4W / SED" or "8W / SED").
factor; adipocyte diameter binned in approximately 5 micron intervals.
factor; the sex of the rat with levels "Female" and "Male".
numeric; ratio of the trained adipocyte rate to the sedentary adipocyte rate. See details.
numeric; standard error for the ratio.
integer; degrees of freedom for the test.
numeric; lower bounds of the 95% confidence interval.
numeric; upper bounds of the 95% confidence interval.
integer; value for the null hypothesis: the ratio
specified by contrast is 1.
numeric; Z-statistic.
numeric; Dunnett p-value.
Adipocytes are binned in approximately 5 micron intervals according
to their diameter (diameter_bin). The number of adipocytes in each
bin per animal, as well as the total number of adipocytes are tallied per
animal. The log of the total adipocytes per animal is included as an offset
term in a negative binomial regression model that contains all main effects
and interactions between sex, timepoint, and
diameter_bin as predictors of the number of binned adipocytes. The
offset term allows for modeling of the number of binned adipocytes per
total number of adipocytes by animal (modeled as a rate).
Within each combination of sex and diameter bin, the Dunnett procedure is applied to test for differences between the trained timepoints (4W, 8W) and the sedentary group (SED).
See vignette("ANALYTES_STATS") for details.