FGSEA of the metabolomics differential analysis results using the Metabolomics Workbench RefMet chemical subclasses.
METAB_FGSEAA named list of 3 data.frame objects. Similar to what is in
GO_FGSEA.
Metabolites were grouped according to their RefMet subclass and FGSEA was performed the same as for gene sets. Only those subclasses with at least 10 metabolites, after filtering to what was detected in WAT, were tested for enrichment.
Fahy, E., & Subramaniam, S. (2020). RefMet: A reference nomenclature for metabolomics. Nature Methods, 17(12), 1173–1174. https://doi.org/10.1038/s41592-020-01009-y