Kinase-substrate relationship data used to infer kinase activity from changes in phosphorylation sites.
PSP_KINASE_SUBSTRATEAn object of class data.frame with 12684 rows and 16 columns:
character; gene symbol.
character; kinase.
character; kinase UniProt accession.
character; kinase organism. Only "human".
character; substrate.
integer; substrate Entrez gene ID.
character; substrate UniProt accession.
character; substrate gene.
character; substrate organism. Only "human".
character; modification site (S, T, or Y followed by amino acid position.)
character; unique identifier for a modification site and its homologous sites in all proteoforms and species.
character; site flanking sequence. The amino acid for the site itself is lowercase. If the site is near the start or end of the protein sequence, the flanking sequence will be padded with underscores.
character; pfam domain for the modification site.
character; in vivo kinase assay/reaction.
character; in vitro kinase assay/reaction.
character; unknown.
The "Kinase_Substrate_Dataset.xlsx" file, downloaded from v6.6.0.4 of PhosphoSitePlus on 2022-06-05 (https://www.phosphosite.org/staticDownloads), was filtered to human kinases and substrates. Additionally, instances of auto-phosphorylation were removed.
Hornbeck, P. V., Zhang, B., Murray, B., Kornhauser, J. M., Latham, V., & Skrzypek, E. (2015). PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic acids research, 43(Database issue), D512–D520. https://doi.org/10.1093/nar/gku1267